NP_001091874.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
44,958 Da
NCBI Official Full Name
nuclear receptor subfamily 1 group I member 2 isoform 2
NCBI Official Synonym Full Names
nuclear receptor subfamily 1, group I, member 2
NCBI Official Synonym Symbols
PXR; SXR; PXR1; mPXR; PXR.1; PXR.2 [Similar Products]
NCBI Protein Information
nuclear receptor subfamily 1 group I member 2
UniProt Protein Name
Nuclear receptor subfamily 1 group I member 2
UniProt Synonym Protein Names
Orphan nuclear receptor PXR; Pregnane X receptor
UniProt Synonym Gene Names
UniProt Comments for PXR
PXR: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. Heterodimer with RXR. Interacts with NCOA1. Expressed in liver, colon and small intestine. Belongs to the nuclear hormone receptor family. NR1 subfamily. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 16|16 B3
Cellular Component: intermediate filament cytoskeleton; nuclear body; nucleoplasm; nucleus
Molecular Function: DNA binding; DNA binding transcription factor activity; drug binding; ligand-dependent nuclear receptor activity; metal ion binding; protein binding; sequence-specific DNA binding; steroid hormone receptor activity; zinc ion binding
Biological Process: drug export; exogenous drug catabolic process; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; steroid hormone mediated signaling; transcription, DNA-dependent; xenobiotic metabolic process; xenobiotic transport
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Pathways associated with anti-PXR antibody
Diseases associated with anti-PXR antibody
Organs/Tissues associated with anti-PXR antibody
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