NP_000563.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
20,517 Da
NCBI Official Full Name
interleukin-10
NCBI Official Synonym Full Names
interleukin 10
NCBI Official Synonym Symbols
CSIF; TGIF; GVHDS; IL-10; IL10A [Similar Products]
NCBI Protein Information
interleukin-10
UniProt Protein Name
Interleukin-10
UniProt Synonym Protein Names
Cytokine synthesis inhibitory factor; CSIF
UniProt Synonym Gene Names
NCBI Summary for IL10
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
UniProt Comments for IL10
Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.
Research Articles on IL10
Precautions
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Disclaimer
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Products associated with IL10 antibody pair kit
Pathways associated with IL10 antibody pair kit
Diseases associated with IL10 antibody pair kit
Organs/Tissues associated with IL10 antibody pair kit
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