NP_001269278.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
osteoclast-associated immunoglobulin-like receptor isoform 6
NCBI Official Synonym Full Names
osteoclast associated, immunoglobulin-like receptor
NCBI Protein Information
osteoclast-associated immunoglobulin-like receptor
UniProt Protein Name
Osteoclast-associated immunoglobulin-like receptor
UniProt Synonym Protein Names
Polymeric immunoglobulin receptor 3; PIgR-3; PIgR3; Poly-Ig receptor 3
UniProt Synonym Gene Names
Osteoclast-associated receptor; hOSCAR; PIgR-3; PIgR3; Poly-Ig receptor 3 [Similar Products]
NCBI Summary for OSCAR
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
UniProt Comments for OSCAR
OSCAR: Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation. Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 19q13.42
Cellular Component: extracellular region; integral component of membrane; plasma membrane
Biological Process: neutrophil degranulation; regulation of immune response
Research Articles on OSCAR
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Products associated with anti-OSCAR antibody
Pathways associated with anti-OSCAR antibody
Diseases associated with anti-OSCAR antibody
Organs/Tissues associated with anti-OSCAR antibody
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