AAV91344.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,729 Da
NCBI Official Full Name
cyclin D1, partial
NCBI Official Synonym Full Names
cyclin D1
NCBI Protein Information
G1/S-specific cyclin-D1
UniProt Protein Name
G1/S-specific cyclin-D1
UniProt Synonym Protein Names
B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene
UniProt Synonym Gene Names
NCBI Summary for CCND1
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]
UniProt Comments for CCND1
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
Research Articles on CCND1
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Products associated with CCND1 antibody pair kit
Pathways associated with CCND1 antibody pair kit
Diseases associated with CCND1 antibody pair kit
Organs/Tissues associated with CCND1 antibody pair kit
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