AAC14352.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
138,908 Da
NCBI Official Full Name
L1 cell adhesion molecule
NCBI Official Synonym Full Names
L1 cell adhesion molecule
NCBI Official Synonym Symbols
S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1 [Similar Products]
NCBI Protein Information
neural cell adhesion molecule L1
UniProt Protein Name
Neural cell adhesion molecule L1
UniProt Synonym Protein Names
CD_antigen: CD171
UniProt Synonym Gene Names
NCBI Summary for L1CAM
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons. [provided by RefSeq, May 2013]
UniProt Comments for L1CAM
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.
Research Articles on L1CAM
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Products associated with L1CAM antibody pair kit
Pathways associated with L1CAM antibody pair kit
Diseases associated with L1CAM antibody pair kit
Organs/Tissues associated with L1CAM antibody pair kit
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