AAI36326.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51,045 Da
NCBI Official Full Name
Alkaline phosphatase, liver/bone/kidney
NCBI Official Synonym Full Names
alkaline phosphatase, liver/bone/kidney
NCBI Official Synonym Symbols
HOPS; TNAP; APTNAP; TNSALP; AP-TNAP [Similar Products]
NCBI Protein Information
alkaline phosphatase, tissue-nonspecific isozyme
UniProt Protein Name
Alkaline phosphatase, tissue-nonspecific isozyme
UniProt Synonym Protein Names
Alkaline phosphatase liver/bone/kidney isozyme
UniProt Synonym Gene Names
NCBI Summary for ALPL
This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]
UniProt Comments for ALPL
This isozyme may play a role in skeletal mineralization.
Research Articles on ALPL
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Pathways associated with ALPL antibody pair kit
Diseases associated with ALPL antibody pair kit
Organs/Tissues associated with ALPL antibody pair kit
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