NP_055807.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
100,745 Da
NCBI Official Full Name
disheveled-associated activator of morphogenesis 1 isoform 1
NCBI Official Synonym Full Names
dishevelled associated activator of morphogenesis 1
NCBI Protein Information
disheveled-associated activator of morphogenesis 1
UniProt Protein Name
Disheveled-associated activator of morphogenesis 1
UniProt Synonym Gene Names
NCBI Summary for DAAM1
Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]
UniProt Comments for DAAM1
Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells ().
Research Articles on DAAM1
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Products associated with DAAM1 antibody pair kit
Pathways associated with DAAM1 antibody pair kit
Diseases associated with DAAM1 antibody pair kit
Organs/Tissues associated with DAAM1 antibody pair kit
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