NP_001138932.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
12,625 Da
NCBI Official Full Name
homeodomain-only protein isoform c
NCBI Official Synonym Full Names
HOP homeobox
NCBI Official Synonym Symbols
HOD; HOP; OB1; LAGY; TOTO; CAMEO; NECC1; SMAP31 [Similar Products]
NCBI Protein Information
homeodomain-only protein
UniProt Protein Name
Homeodomain-only protein
UniProt Synonym Protein Names
Lung cancer-associated Y protein; Not expressed in choriocarcinoma protein 1; Odd homeobox protein 1
UniProt Synonym Gene Names
NCBI Summary for HOP
The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2009]
UniProt Comments for HOP
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256).
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Products associated with HOP antibody pair kit
Diseases associated with HOP antibody pair kit
Organs/Tissues associated with HOP antibody pair kit
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