NP_002473.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
78,450 Da
NCBI Official Full Name
nuclear autoantigenic sperm protein isoform 2
NCBI Official Synonym Full Names
nuclear autoantigenic sperm protein
NCBI Protein Information
nuclear autoantigenic sperm protein
UniProt Protein Name
Nuclear autoantigenic sperm protein
UniProt Synonym Gene Names
NCBI Summary for NASP
This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]
UniProt Comments for NASP
Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.
Research Articles on NASP
Precautions
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Disclaimer
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Products associated with NASP antibody pair kit
Diseases associated with NASP antibody pair kit
Organs/Tissues associated with NASP antibody pair kit
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