NP_002325.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
212,045 Da
NCBI Official Full Name
low-density lipoprotein receptor-related protein 4
NCBI Official Synonym Full Names
LDL receptor related protein 4
NCBI Official Synonym Symbols
CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2 [Similar Products]
NCBI Protein Information
low-density lipoprotein receptor-related protein 4
UniProt Protein Name
Low-density lipoprotein receptor-related protein 4
UniProt Synonym Protein Names
Multiple epidermal growth factor-like domains 7
UniProt Synonym Gene Names
NCBI Summary for LRP4
This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. [provided by RefSeq, May 2010]
UniProt Comments for LRP4
Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation ().
Research Articles on LRP4
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Products associated with LRP4 antibody pair kit
Pathways associated with LRP4 antibody pair kit
Diseases associated with LRP4 antibody pair kit
Organs/Tissues associated with LRP4 antibody pair kit
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