EAW57705.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,645 Da
NCBI Official Full Name
wingless-type MMTV integration site family, member 3
NCBI Official Synonym Full Names
Wnt family member 3
NCBI Official Synonym Symbols
NCBI Protein Information
proto-oncogene Wnt-3
UniProt Protein Name
Proto-oncogene Wnt-3
UniProt Synonym Protein Names
Proto-oncogene Int-4 homolog
UniProt Synonym Gene Names
NCBI Summary for WNT3
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]
UniProt Comments for WNT3
Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube ().
Research Articles on WNT3
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Products associated with WNT3 antibody pair kit
Pathways associated with WNT3 antibody pair kit
Diseases associated with WNT3 antibody pair kit
Organs/Tissues associated with WNT3 antibody pair kit
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