AAH70160.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
91,673 Da
NCBI Official Full Name
SP140 nuclear body protein
NCBI Official Synonym Full Names
SP140 nuclear body protein
NCBI Protein Information
nuclear body protein SP140
UniProt Protein Name
Nuclear body protein SP140
UniProt Synonym Protein Names
Lymphoid-restricted homolog of Sp100
UniProt Synonym Gene Names
NCBI Summary for SP140
This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]
UniProt Comments for SP140
Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577). May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577). May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382).
Research Articles on SP140
Precautions
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Disclaimer
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Products associated with SP140 antibody pair kit
Diseases associated with SP140 antibody pair kit
Organs/Tissues associated with SP140 antibody pair kit
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