NP_998734.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,196 Da
NCBI Official Full Name
nebulette isoform 2
NCBI Official Synonym Full Names
nebulette
NCBI Official Synonym Symbols
NCBI Protein Information
nebulette
UniProt Protein Name
Nebulette
UniProt Synonym Protein Names
Actin-binding Z-disk protein
UniProt Synonym Gene Names
UniProt Entry Name
NEBL_HUMAN
NCBI Summary for NEBL
This gene encodes a nebulin like protein that is abundantly expressed in cardiac muscle. The encoded protein binds actin and interacts with thin filaments and Z-line associated proteins in striated muscle. This protein may be involved in cardiac myofibril assembly. A shorter isoform of this protein termed LIM nebulette is expressed in non-muscle cells and may function as a component of focal adhesion complexes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
UniProt Comments for NEBL
NEBL: Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the assembly of focal adhesion. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Actin-binding
Chromosomal Location of Human Ortholog: 10p12
Cellular Component: I band; stress fiber; Z disc
Molecular Function: actin filament binding; cytoskeletal protein binding; filamin binding; protein binding; structural constituent of muscle; tropomyosin binding
Research Articles on NEBL
Precautions
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Products associated with anti-NEBL antibody
Diseases associated with anti-NEBL antibody
Organs/Tissues associated with anti-NEBL antibody
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