NP_002258.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
importin subunit alpha-4
NCBI Official Synonym Full Names
karyopherin subunit alpha 3
NCBI Official Synonym Symbols
SRP1; SRP4; IPOA4; hSRP1; SRP1gamma [Similar Products]
NCBI Protein Information
importin subunit alpha-4
UniProt Protein Name
Importin subunit alpha-4
UniProt Synonym Protein Names
Importin alpha Q2; Qip2; Karyopherin subunit alpha-3; SRP1-gamma
UniProt Synonym Gene Names
NCBI Summary for KPNA3
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. [provided by RefSeq, Jan 2009]
UniProt Comments for KPNA3
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9.CautionWas termed importin alpha-4.
Research Articles on KPNA3
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Products associated with anti-KPNA3 antibody
Pathways associated with anti-KPNA3 antibody
Diseases associated with anti-KPNA3 antibody
Organs/Tissues associated with anti-KPNA3 antibody
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