NP_001832.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,681 Da
NCBI Official Full Name
cannabinoid receptor 2
NCBI Official Synonym Full Names
cannabinoid receptor 2
NCBI Protein Information
cannabinoid receptor 2
UniProt Protein Name
Cannabinoid receptor 2
UniProt Synonym Protein Names
CX5
UniProt Synonym Gene Names
UniProt Entry Name
CNR2_HUMAN
NCBI Summary for CNR2
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]
UniProt Comments for CNR2
CNR2: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component: dendrite; extrinsic to internal side of plasma membrane; integral to plasma membrane; perikaryon; plasma membrane
Molecular Function: cannabinoid receptor activity
Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; immune response; inflammatory response; negative regulation of action potential; negative regulation of inflammatory response; negative regulation of mast cell activation; negative regulation of nitric-oxide synthase activity; negative regulation of synaptic transmission, GABAergic; response to amphetamine; response to lipopolysaccharide; sensory perception of pain
Research Articles on CNR2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with CNR2 blocking peptide
Pathways associated with CNR2 blocking peptide
Diseases associated with CNR2 blocking peptide
Organs/Tissues associated with CNR2 blocking peptide
|