NP_003957.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
120,615 Da
NCBI Official Full Name
semaphorin 5A
NCBI Official Synonym Full Names
semaphorin 5A
NCBI Official Synonym Symbols
NCBI Protein Information
semaphorin-5A
UniProt Protein Name
Semaphorin-5A
UniProt Synonym Protein Names
Semaphorin-F; Sema F
UniProt Synonym Gene Names
UniProt Entry Name
SEM5A_HUMAN
NCBI Summary for SEMA5A
This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010]
UniProt Comments for SEMA5A
SEMA5A: a single-pass type I membrane protein that may act as positive axonal guidance cues.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 5p15.2
Cellular Component: integral to membrane; membrane; plasma membrane
Molecular Function: chemorepellent activity; heparan sulfate proteoglycan binding; semaphorin receptor binding; syndecan binding
Biological Process: axonal fasciculation; blood vessel endothelial cell proliferation during sprouting angiogenesis; cell adhesion; cell-cell signaling; diencephalon development; negative chemotaxis; negative regulation of axon extension involved in axon guidance; negative regulation of cell adhesion; nervous system development; neural crest cell migration; positive chemotaxis; positive regulation of actin filament depolymerization; positive regulation of angiogenesis; positive regulation of axon extension involved in axon guidance; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of protein kinase B signaling cascade
Research Articles on SEMA5A
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Products associated with SEMA5A blocking peptide
Pathways associated with SEMA5A blocking peptide
Diseases associated with SEMA5A blocking peptide
Organs/Tissues associated with SEMA5A blocking peptide
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