P51677.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,453 Da
NCBI Official Full Name
C-C chemokine receptor type 3
NCBI Official Synonym Full Names
C-C motif chemokine receptor 3
NCBI Protein Information
C-C chemokine receptor type 3
UniProt Protein Name
C-C chemokine receptor type 3
UniProt Synonym Protein Names
Eosinophil eotaxin receptor; CD_antigen: CD193
UniProt Synonym Gene Names
UniProt Entry Name
CCR3_HUMAN
NCBI Summary for CCR3
The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]
UniProt Comments for CCR3
CCR3: Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, GPCR; Receptor, cytokine; GPCR, family 1; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3p21.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: C-C chemokine receptor activity; chemokine receptor activity; protein binding
Biological Process: cell adhesion; cellular defense response; chemotaxis; elevation of cytosolic calcium ion concentration; G-protein signaling, coupled to cAMP nucleotide second messenger; inflammatory response; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; viral reproduction
Research Articles on CCR3
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Disclaimer
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Products associated with anti-CCR3 antibody
Pathways associated with anti-CCR3 antibody
Diseases associated with anti-CCR3 antibody
Organs/Tissues associated with anti-CCR3 antibody
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