NP_001495
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,715 Da
NCBI Official Full Name
C-X-C chemokine receptor type 3 isoform 1
NCBI Official Synonym Full Names
C-X-C motif chemokine receptor 3
NCBI Official Synonym Symbols
GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R [Similar Products]
NCBI Protein Information
C-X-C chemokine receptor type 3
UniProt Protein Name
C-X-C chemokine receptor type 3
UniProt Synonym Protein Names
CKR-L2; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor; CD_antigen: CD183
UniProt Synonym Gene Names
UniProt Entry Name
CXCR3_HUMAN
NCBI Summary for CXCR3
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
UniProt Comments for CXCR3
CXCR3: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: Xq13
Cellular Component: cytoplasm; cytosol; external side of plasma membrane; integral to plasma membrane; plasma membrane
Molecular Function: C-X-C chemokine binding; C-X-C chemokine receptor activity; chemokine binding; chemokine receptor activity; receptor activity
Biological Process: angiogenesis; apoptosis; calcium-mediated signaling; cell adhesion; cell motility; cell surface receptor linked signal transduction; chemotaxis; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; inflammatory response; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; positive regulation of angiogenesis; positive regulation of cAMP metabolic process; positive regulation of cell proliferation; positive regulation of chemotaxis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of transcription from RNA polymerase II promoter; regulation of leukocyte migration
Research Articles on CXCR3
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Products associated with anti-CXCR3 antibody
Pathways associated with anti-CXCR3 antibody
Diseases associated with anti-CXCR3 antibody
Organs/Tissues associated with anti-CXCR3 antibody
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