AAH03973.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
66,506 Da
NCBI Official Full Name
Loxl1 protein, partial
NCBI Official Synonym Full Names
lysyl oxidase-like 1
NCBI Official Synonym Symbols
NCBI Protein Information
lysyl oxidase homolog 1
UniProt Protein Name
Lysyl oxidase homolog 1
UniProt Synonym Protein Names
Lysyl oxidase 2; Lysyl oxidase-like protein 1
UniProt Synonym Gene Names
UniProt Entry Name
LOXL1_MOUSE
UniProt Comments for LOXL1
LOXL1: Active on elastin and collagen substrates. Genetic variations in LOXL1 are a cause of susceptibility to exfoliation syndrome (XFS); also called exfoliation glaucoma (XFG). XFS is a disorder characterized by accumulation of abnormal fibrillar deposits in the anterior segment of the eye. In addition to being a cause of glaucoma and glaucomatous optic neuropathy, exfoliation syndrome has also been associated with lens zonule weakness, cataract formation, and systemic vascular complications due to deposition of exfoliation material in extraocular tissues. Susceptibility to exfoliation syndrome is conferred by a risk haplotype that includes two LOXL1 coding non-synonymous SNPs (Arg141Leu and Gly153Asp) and one intronic SNP. Arg141Leu and Gly153Asp are sufficient to confer disease susceptibility in some populations. Belongs to the lysyl oxidase family.
Protein type: EC 1.4.3.-; Secreted, signal peptide; Extracellular matrix; Oxidoreductase; Secreted
Cellular Component: acrosome; basement membrane; cytoplasm; extracellular matrix; extracellular region; proteinaceous extracellular matrix
Molecular Function: aspartate oxidase activity; copper ion binding; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor; protein binding
Research Articles on LOXL1
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Products associated with anti-LOXL1 antibody
Pathways associated with anti-LOXL1 antibody
Diseases associated with anti-LOXL1 antibody
Organs/Tissues associated with anti-LOXL1 antibody
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