Q9Y6R4.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
177,014 Da
NCBI Official Full Name
Mitogen-activated protein kinase kinase kinase 4
NCBI Official Synonym Full Names
mitogen-activated protein kinase kinase kinase 4
NCBI Official Synonym Symbols
MTK1; MEKK4; MEKK 4; MAPKKK4; PRO0412 [Similar Products]
NCBI Protein Information
mitogen-activated protein kinase kinase kinase 4
UniProt Protein Name
Mitogen-activated protein kinase kinase kinase 4
UniProt Synonym Protein Names
MAP three kinase 1; MAPK/ERK kinase kinase 4; MEK kinase 4; MEKK 4
UniProt Synonym Gene Names
UniProt Entry Name
M3K4_HUMAN
NCBI Summary for MAP3K4
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, May 2014]
UniProt Comments for MAP3K4
Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.
Research Articles on MAP3K4
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Products associated with anti-MAP3K4 antibody
Pathways associated with anti-MAP3K4 antibody
Diseases associated with anti-MAP3K4 antibody
Organs/Tissues associated with anti-MAP3K4 antibody
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