NP_543169
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
66,142 Da
NCBI Official Full Name
dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 4
NCBI Official Synonym Full Names
phosphodiesterase 11A
NCBI Protein Information
dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
UniProt Protein Name
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
UniProt Synonym Protein Names
cAMP and cGMP phosphodiesterase 11A
UniProt Entry Name
PDE11_RAT
NCBI Summary for PDE11A
hydrolyzes cyclic nucleotides cAMP and cGMP, downregulating their activity [RGD, Feb 2006]
UniProt Comments for PDE11A
PDE11A: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively. Defects in PDE11A are the cause of primary pigmented nodular adrenocortical disease type 2 (PPNAD2). Primary pigmented nodular adrenocortical disease is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. PPNAD2 is characterized by adrenal glands with overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. PPNAD2 leads to Cushing syndrome. Belongs to the cyclic nucleotide phosphodiesterase family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.4.17; Mitochondrial; Nucleotide Metabolism - purine; EC 3.1.4.35; Phosphodiesterase
Cellular Component: cytosol; perikaryon
Molecular Function: 3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cAMP binding; cGMP binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; cyclic-nucleotide phosphodiesterase activity; metal ion binding
Biological Process: cAMP catabolic process; cGMP catabolic process; signal transduction
Research Articles on PDE11A
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Pathways associated with anti-PDE11A antibody
Diseases associated with anti-PDE11A antibody
Organs/Tissues associated with anti-PDE11A antibody
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