P20096.2
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
16,247 Da
NCBI Official Full Name
Interleukin-4
NCBI Official Synonym Full Names
interleukin 4
NCBI Official Synonym Symbols
NCBI Protein Information
interleukin-4; IL-4; BSF-1; B-cell growth factor 1; B-cell stimulatory factor 1; lymphocyte stimulatory factor 1; B-cell IGG differentiation factor
UniProt Protein Name
Interleukin-4
UniProt Synonym Protein Names
B-cell IGG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1
UniProt Synonym Gene Names
UniProt Entry Name
IL4_RAT
NCBI Summary for IL-4
Th2-type cytokine; may be involved in inflammatory response in eosinophils [RGD, Feb 2006]
UniProt Comments for IL-4
IL4: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Belongs to the IL-4/IL-13 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide; Cell cycle regulation; Cytokine
Cellular Component: extracellular space; external side of plasma membrane
Molecular Function: growth factor activity; cytokine activity; interleukin-4 receptor binding
Biological Process: positive regulation of isotype switching to IgG isotypes; negative regulation of osteoclast differentiation; positive regulation of transcription, DNA-dependent; microglial cell activation; regulation of proton transport; female pregnancy; positive regulation of activated T cell proliferation; response to organic cyclic substance; positive regulation of isotype switching to IgE isotypes; positive regulation of interleukin-10 production; B cell costimulation; positive regulation of MHC class II biosynthetic process; positive regulation of cell proliferation; positive regulation of B cell proliferation; positive regulation of T cell proliferation; positive regulation of interleukin-13 production; negative regulation of macrophage activation; response to nutrient; response to drug; cholesterol metabolic process; regulation of immune response; negative regulation of chronic inflammatory response; B cell activation; negative regulation of nitric oxide biosynthetic process; negative regulation of acute inflammatory response; positive regulation of mast cell degranulation; defense response to protozoan; positive regulation of peptidyl-tyrosine phosphorylation; T-helper 1 cell lineage commitment; positive regulation of immunoglobulin production; response to ethanol; positive regulation of chemokine biosynthetic process; positive regulation of T cell differentiation; positive regulation of tyrosine phosphorylation of Stat5 protein; innate immune response in mucosa; retina development in camera-type eye; response to cytokine stimulus; positive regulation of B cell activation; regulation of inflammatory response; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; T-helper 2 cell differentiation; positive regulation of defense response to virus by host; negative regulation of transcription, DNA-dependent; negative regulation of T cell activation; regulation of T cell activation
Research Articles on IL-4
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Products associated with anti-IL-4 antibody
Pathways associated with anti-IL-4 antibody
Diseases associated with anti-IL-4 antibody
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