NP_001275903.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
80,263 Da
NCBI Official Full Name
disintegrin and metalloproteinase domain-containing protein 12 isoform 4 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase domain 12
NCBI Official Synonym Symbols
MCMP; MLTN; CAR10; MLTNA; MCMPMltna; ADAM12-OT1 [Similar Products]
NCBI Protein Information
disintegrin and metalloproteinase domain-containing protein 12
UniProt Protein Name
Disintegrin and metalloproteinase domain-containing protein 12
UniProt Synonym Protein Names
Meltrin-alpha
UniProt Synonym Gene Names
UniProt Entry Name
ADA12_HUMAN
NCBI Summary for ADAM12
This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]
UniProt Comments for ADAM12
ADAM12: contains a disintegrin and metalloprotease (ADAM) domain 12, which is a member of the ADAM protein family. Involved in skeletal muscle regeneration, specifically at the onset of cell fusion, and the differentiation of macrophage-derived giant cells (MGC) and osteoclasts. 2 alternative splicing isoforms have been described: a shorter secreted form and a longer membrane-bound form. The shorter form stimulates myogenesis.
Protein type: Motility/polarity/chemotaxis; Protease; Membrane protein, integral; EC 3.4.24.-
Chromosomal Location of Human Ortholog: 10q26
Cellular Component: nucleoplasm; mitochondrion; extracellular region; integral to membrane; plasma membrane
Molecular Function: protein binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity; SH3 domain binding
Biological Process: epidermal growth factor receptor signaling pathway; cell adhesion; proteolysis; myoblast fusion
Research Articles on ADAM12
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Products associated with ADAM12 blocking peptide
Pathways associated with ADAM12 blocking peptide
Diseases associated with ADAM12 blocking peptide
Organs/Tissues associated with ADAM12 blocking peptide
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