NP_005199.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
beta-crystallin A3
NCBI Official Synonym Full Names
crystallin, beta A1
NCBI Protein Information
beta-crystallin A3
UniProt Protein Name
Beta-crystallin A3
UniProt Synonym Gene Names
UniProt Entry Name
CRBA1_HUMAN
NCBI Summary for CRYBA1
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta acidic group member, encodes two proteins (crystallin, beta A3 and crystallin, beta A1) from a single mRNA, the latter protein is 17 aa shorter than crystallin, beta A3 and is generated by use of an alternate translation initiation site. Deletion of exons 3 and 4 causes the autosomal dominant disease 'zonular cataract with sutural opacities'. [provided by RefSeq, Jul 2008]
UniProt Comments for CRYBA1
CRYBA1: a major structural protein of the eye lens. A member of the beta/gamma-crystallin family. Defects are the cause of congenital zonular cataract with sutural opacities. Two splice-variant isoforms have been described.
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; protein homodimerization activity; structural constituent of eye lens
Biological Process: lens development in camera-type eye; visual perception
Disease: Cataract 10, Multiple Types
Product References and Citations for anti-CRYBA1 antibody
Xu, J., et al. Mol. Vis. 16, 438-444 (2010) : Gu, Z., et al. Mol. Vis. 16, 154-160 (2010) : Srivastava, K., et al. Biochemistry 48(30):7179-7189(2009) Gupta, R., et al. J. Biol. Chem. 284(27):18481-18492(2009) Takata, T., et al. Mol. Vis. 15, 241-249 (2009) :
Research Articles on CRYBA1
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Products associated with anti-CRYBA1 antibody
Diseases associated with anti-CRYBA1 antibody
Organs/Tissues associated with anti-CRYBA1 antibody
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