NP_116241.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cysteine protease ATG4C
NCBI Official Synonym Full Names
autophagy related 4C, cysteine peptidase
NCBI Protein Information
cysteine protease ATG4C
UniProt Protein Name
Cysteine protease ATG4C
UniProt Synonym Protein Names
AUT-like 3 cysteine endopeptidase; Autophagin-3; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C
UniProt Synonym Gene Names
UniProt Entry Name
ATG4C_HUMAN
NCBI Summary for ATG4C
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for ATG4C
ATG4C: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Highly expressed in skeletal muscle, heart, liver and testis. Inhibited by N-ethylmaleimide. Belongs to the peptidase C54 family.
Protein type: Autophagy; Protease; EC 3.4.22.-; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 1p31.3
Cellular Component: cytoplasm; extracellular region; cytosol
Molecular Function: peptidase activity; cysteine-type endopeptidase activity
Biological Process: protein delipidation; mitochondrion degradation; autophagy; protein processing; C-terminal protein lipidation; proteolysis; protein targeting to membrane; autophagic vacuole formation; cellular response to nitrogen starvation
Product References and Citations for anti-ATG4C antibody
Baehrecke EH. Nat Rev Mol Cell Biol. 6(6):505-10. (2005) Lum JJ, et al. Nat Rev Mol Cell Biol. 6(6):439-48. (2005) Greenberg JT. Dev Cell. 8(6):799-801. (2005) Levine B. Cell. 120(2):159-62. (2005) Shintani T and Klionsky DJ. Science. 306(5698):990-5. (2004)
Research Articles on ATG4C
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Products associated with anti-ATG4C antibody
Diseases associated with anti-ATG4C antibody
Organs/Tissues associated with anti-ATG4C antibody
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