NP_001172006.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
rho GDP-dissociation inhibitor 1 isoform a
NCBI Official Synonym Full Names
Rho GDP dissociation inhibitor (GDI) alpha
NCBI Official Synonym Symbols
GDIA1; NPHS8; RHOGDI; RHOGDI-1; HEL-S-47e [Similar Products]
NCBI Protein Information
rho GDP-dissociation inhibitor 1
UniProt Protein Name
Rho GDP-dissociation inhibitor 1
UniProt Synonym Protein Names
Rho-GDI alpha
UniProt Synonym Gene Names
UniProt Entry Name
GDIR1_HUMAN
NCBI Summary for ARHGDIA
This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Comments for ARHGDIA
RhoGDI alpha: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Monomer. Forms a heterodimer with RAC1. Interacts with FER. Belongs to the Rho GDI family.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; G protein regulator, misc.; Apoptosis; Cell development/differentiation
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: cytoskeleton; immunological synapse; cytosol
Molecular Function: protein binding; Rho GDP-dissociation inhibitor activity; GTPase activator activity
Biological Process: nerve growth factor receptor signaling pathway; negative regulation of cell adhesion; regulation of axonogenesis; Rho protein signal transduction; regulation of small GTPase mediated signal transduction; regulation of protein localization; small GTPase mediated signal transduction; positive regulation of axonogenesis; negative regulation of axonogenesis; cell motility; negative regulation of cell migration; negative regulation of apoptosis; positive regulation of GTPase activity
Disease: Nephrotic Syndrome, Type 8
Product References and Citations for anti-ARHGDIA antibody
Qiao,J., etc, Am. J. Physiol., Cell Physiol. 295 (5), C1161-C1168 (2008)
Research Articles on ARHGDIA
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Products associated with anti-ARHGDIA antibody
Diseases associated with anti-ARHGDIA antibody
Organs/Tissues associated with anti-ARHGDIA antibody
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