NP_057025.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
V-type proton ATPase subunit H isoform 1
NCBI Official Synonym Full Names
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
NCBI Official Synonym Symbols
SFD; NBP1; VMA13; CGI-11; MSTP042; SFDbeta; SFDalpha [Similar Products]
NCBI Protein Information
V-type proton ATPase subunit H
UniProt Protein Name
V-type proton ATPase subunit H
UniProt Synonym Protein Names
Nef-binding protein 1; NBP1; Protein VMA13 homolog; V-ATPase 50/57 kDa subunits; Vacuolar proton pump subunit H; Vacuolar proton pump subunit SFD
UniProt Synonym Gene Names
UniProt Entry Name
VATH_HUMAN
NCBI Summary for ATP6V1H
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this gene may play a role in the development of type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
UniProt Comments for ATP6V1H
ATP6V1H: Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes. Belongs to the V-ATPase H subunit family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase; Energy Metabolism - oxidative phosphorylation; EC 3.6.3.14
Chromosomal Location of Human Ortholog: 8q11.2
Cellular Component: lysosomal membrane; plasma membrane; vacuolar proton-transporting V-type ATPase, V1 domain; cytosol
Molecular Function: protein binding; ATPase activity; hydrogen ion transporting ATPase activity, rotational mechanism; enzyme regulator activity
Biological Process: interaction with host; vacuolar acidification; viral reproduction; metabolic process; cellular iron ion homeostasis; regulation of catalytic activity; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; endocytosis; transmembrane transport; regulation of defense response to virus by virus
Product References and Citations for anti-ATP6V1H antibody
Fuster, D.G., et al. Kidney Int. 73(10):1151-1158(2008) Stove, V., et al. J. Virol. 79(17):11422-11433(2005) Morel, N. Biol. Cell 95(7):453-457(2003)
Research Articles on ATP6V1H
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Products associated with anti-ATP6V1H antibody
Pathways associated with anti-ATP6V1H antibody
Diseases associated with anti-ATP6V1H antibody
Organs/Tissues associated with anti-ATP6V1H antibody
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