P16615.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
109,734 Da
NCBI Official Full Name
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
NCBI Official Synonym Full Names
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
NCBI Protein Information
sarcoplasmic/endoplasmic reticulum calcium ATPase 2
UniProt Protein Name
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
UniProt Synonym Protein Names
Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase
UniProt Synonym Gene Names
UniProt Entry Name
AT2A2_HUMAN
NCBI Summary for ATP2A2
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008]
UniProt Comments for ATP2A2
SERCA2: an intracellular pump located in the sarcoplasmic or endoplasmic reticula of muscle cells. Possesses a Ca(2+)-ATPase activity. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN. Two alternatively spliced isoforms have been described.
Protein type: Membrane protein, integral; Transporter; Transporter, ion channel; EC 3.6.3.8; Endoplasmic reticulum; Cell adhesion; Hydrolase; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to plasma membrane; membrane; sarcoplasmic reticulum; sarcoplasmic reticulum membrane
Molecular Function: calcium ion binding; calcium-transporting ATPase activity; enzyme binding; protein binding
Biological Process: cell adhesion; elevation of endoplasmic reticulum calcium ion concentration; endoplasmic reticulum calcium ion homeostasis; epidermis development; positive regulation of heart rate
Disease: Acrokeratosis Verruciformis; Darier-white Disease
Research Articles on ATP2A2
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Products associated with ATP2A2 blocking peptide
Pathways associated with ATP2A2 blocking peptide
Diseases associated with ATP2A2 blocking peptide
Organs/Tissues associated with ATP2A2 blocking peptide
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