O75915.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,615 Da
NCBI Official Full Name
PRA1 family protein 3
NCBI Official Synonym Full Names
ADP ribosylation factor like GTPase 6 interacting protein 5
NCBI Official Synonym Symbols
JWA; jmx; hp22; PRAF3; Yip6b; DERP11; HSPC127; addicsin; GTRAP3-18 [Similar Products]
NCBI Protein Information
PRA1 family protein 3
UniProt Protein Name
PRA1 family protein 3
UniProt Synonym Protein Names
ADP-ribosylation factor-like protein 6-interacting protein 5; ARL-6-interacting protein 5; Aip-5; Cytoskeleton-related vitamin A-responsive protein; Dermal papilla-derived protein 11; GTRAP3-18; Glutamate transporter EAAC1-interacting protein; JM5; Prenylated Rab acceptor protein 2; Protein JWa; Putative MAPK-activating protein PM27
UniProt Synonym Gene Names
UniProt Entry Name
PRAF3_HUMAN
NCBI Summary for ARL6IP5
Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008]
UniProt Comments for ARL6IP5
ARL6IP5: Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic. Belongs to the PRA1 family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Cytoskeletal; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 3p14
Cellular Component: endoplasmic reticulum; membrane
Molecular Function: protein binding
Biological Process: induction of apoptosis by oxidative stress; L-glutamate transport; negative regulation of L-glutamate transport; positive regulation of apoptosis; positive regulation of caspase activity; positive regulation of stress-activated MAPK cascade
Research Articles on ARL6IP5
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Pathways associated with ARL6IP5 blocking peptide
Diseases associated with ARL6IP5 blocking peptide
Organs/Tissues associated with ARL6IP5 blocking peptide
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