P40394.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,467 Da
NCBI Official Full Name
Alcohol dehydrogenase class 4 mu/sigma chain
NCBI Official Synonym Full Names
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
NCBI Official Synonym Symbols
NCBI Protein Information
alcohol dehydrogenase class 4 mu/sigma chain
UniProt Protein Name
Alcohol dehydrogenase class 4 mu/sigma chain
UniProt Synonym Protein Names
Alcohol dehydrogenase class IV mu/sigma chain; Gastric alcohol dehydrogenase; Retinol dehydrogenase
UniProt Entry Name
ADH7_HUMAN
NCBI Summary for ADH7
This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
UniProt Comments for ADH7
ADH7: Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism. Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; Oxidoreductase; Cofactor and Vitamin Metabolism - retinol; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Amino Acid Metabolism - tyrosine; EC 1.1.1.1; Lipid Metabolism - fatty acid
Chromosomal Location of Human Ortholog: 4q23-q24
Cellular Component: cytosol
Molecular Function: alcohol dehydrogenase activity; alcohol dehydrogenase activity, zinc-dependent; aldehyde oxidase activity; ethanol binding; receptor antagonist activity; retinol binding; retinol dehydrogenase activity
Biological Process: ethanol oxidation; fatty acid omega-oxidation; response to bacterium; response to ethanol; retinoid metabolic process
Research Articles on ADH7
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Pathways associated with ADH7 blocking peptide
Diseases associated with ADH7 blocking peptide
Organs/Tissues associated with ADH7 blocking peptide
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