P30556.1
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41,061 Da
NCBI Official Full Name
Type-1 angiotensin II receptor
NCBI Official Synonym Full Names
angiotensin II receptor type 1
NCBI Official Synonym Symbols
AT1; AG2S; AT1B; AT1R; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1B [Similar Products]
NCBI Protein Information
type-1 angiotensin II receptor
UniProt Protein Name
Type-1 angiotensin II receptor
UniProt Synonym Protein Names
AT1AR; AT1BR; Angiotensin II type-1 receptor; AT1
UniProt Synonym Gene Names
UniProt Entry Name
AGTR1_HUMAN
NCBI Summary for AGTR1
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
UniProt Comments for AGTR1
AT1: receptor for angiotensin II. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. Mediates the major cardiovascular effects of angiotensin II. May play role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3q24
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: angiotensin type I receptor activity; angiotensin type II receptor activity; bradykinin receptor binding; protein binding; protein heterodimerization activity
Biological Process: calcium-mediated signaling; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein coupled receptor protein signaling pathway; kidney development; positive regulation of cellular protein metabolic process; positive regulation of inflammatory response; positive regulation of NAD(P)H oxidase activity; positive regulation of phospholipase A2 activity; regulation of inflammatory response; regulation of systemic arterial blood pressure by renin-angiotensin; regulation of vasoconstriction; regulation of vasodilation; renin-angiotensin regulation of blood vessel size; Rho protein signal transduction
Disease: Hypertension, Essential; Renal Tubular Dysgenesis
Research Articles on AGTR1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with AGTR1 blocking peptide
Pathways associated with AGTR1 blocking peptide
Diseases associated with AGTR1 blocking peptide
Organs/Tissues associated with AGTR1 blocking peptide
|