NP_000682.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,395 Da
NCBI Official Full Name
aldehyde dehydrogenase, dimeric NADP-preferring
NCBI Official Synonym Full Names
aldehyde dehydrogenase 3 family member A1
NCBI Protein Information
aldehyde dehydrogenase, dimeric NADP-preferring
UniProt Protein Name
Aldehyde dehydrogenase, dimeric NADP-preferring
UniProt Synonym Protein Names
ALDHIII; Aldehyde dehydrogenase 3; Aldehyde dehydrogenase family 3 member A1
UniProt Synonym Gene Names
UniProt Entry Name
AL3A1_HUMAN
NCBI Summary for ALDH3A1
Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]
UniProt Comments for ALDH3A1
ALDH3A1: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes. Belongs to the aldehyde dehydrogenase family.
Protein type: Amino Acid Metabolism - tyrosine; EC 1.2.1.5; Xenobiotic Metabolism - metabolism by cytochrome P450; Amino Acid Metabolism - histidine; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - phenylalanine
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; extracellular space; integral to membrane; intracellular membrane-bound organelle; nucleoplasm; plasma membrane
Molecular Function: 3-chloroallyl aldehyde dehydrogenase activity; alcohol dehydrogenase (NADP+) activity; aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; benzaldehyde dehydrogenase (NAD+) activity; protein binding
Biological Process: aging; aldehyde metabolic process; positive regulation of cell proliferation; response to cAMP; response to drug; response to glucocorticoid stimulus; response to hypoxia; response to nutrient; xenobiotic metabolic process
Research Articles on ALDH3A1
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Products associated with anti-ALDH3A1 antibody
Pathways associated with anti-ALDH3A1 antibody
Diseases associated with anti-ALDH3A1 antibody
Organs/Tissues associated with anti-ALDH3A1 antibody
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