NP_945320
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,091 Da
NCBI Official Full Name
amino-terminal enhancer of split isoform a
NCBI Official Synonym Full Names
amino-terminal enhancer of split
NCBI Official Synonym Symbols
GRG; ESP1; GRG5; TLE5; AES-1; AES-2; Grg-5 [Similar Products]
NCBI Protein Information
amino-terminal enhancer of split; groucho-related protein 5; gp130-associated protein GAM
UniProt Protein Name
Amino-terminal enhancer of split
UniProt Synonym Protein Names
Gp130-associated protein GAM; Grg-5; Groucho-related protein 5; Protein ESP1; Protein GRG
UniProt Synonym Gene Names
UniProt Entry Name
AES_HUMAN
NCBI Summary for AES
The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for AES
AES: Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Belongs to the WD repeat Groucho/TLE family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: nucleus
Molecular Function: protein binding; transcription corepressor activity
Biological Process: organ morphogenesis; Wnt receptor signaling pathway; transcription, DNA-dependent; multicellular organismal development; regulation of growth; cellular response to extracellular stimulus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of protein binding; skeletal development
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Products associated with anti-AES antibody
Pathways associated with anti-AES antibody
Diseases associated with anti-AES antibody
Organs/Tissues associated with anti-AES antibody
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