NP_037040.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
31,140 Da
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 6
NCBI Official Synonym Full Names
Fas ligand
NCBI Official Synonym Symbols
Fasl; CD95-L; Tnfsf6; Tnlg1a; Apt1Lg1 [Similar Products]
NCBI Protein Information
tumor necrosis factor ligand superfamily member 6
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 6
UniProt Synonym Protein Names
CD95 ligand; CD95-L
UniProt Synonym Gene Names
Apt1Lg1; Cd95l; Fasl; Tnfsf6; CD95-L; Fas ligand; FasL; sFasL; APL; FasL ICD; SPA [Similar Products]
NCBI Summary for FASL
ligand that binds the Fas receptor; plays a role in induction of apoptosis [RGD, Feb 2006]
UniProt Comments for FASL
FasL: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. Homotrimer (Probable). Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Cytokine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 13q22
Cellular Component: caveola; cell surface; cytoplasmic vesicle; external side of plasma membrane; extracellular space; integral component of membrane; lysosomal lumen; membrane raft; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: cytokine activity; death receptor binding; tumor necrosis factor receptor binding
Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process; cellular chloride ion homeostasis; endosomal lumen acidification; immune response; induction of apoptosis via death domain receptors; inflammatory cell apoptotic process; negative regulation of angiogenesis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis; positive regulation of cell proliferation; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of neuron apoptotic process; response to lipopolysaccharide; retinal cell programmed cell death; transcription, DNA-dependent
Research Articles on FASL
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Products associated with anti-FASL antibody
Pathways associated with anti-FASL antibody
Diseases associated with anti-FASL antibody
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