NP_000206.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Predicted Molecular Mass: 32.3kDa Accurate Molecular Mass: 32kDa as determined by SDS-PAGE reducing conditions.
NCBI Official Full Name
tyrosine-protein kinase JAK3
NCBI Official Synonym Full Names
Janus kinase 3
NCBI Official Synonym Symbols
JAKL; LJAK; JAK-3; L-JAK; JAK3_HUMAN [Similar Products]
NCBI Protein Information
tyrosine-protein kinase JAK3; leukocyte Janus kinase; Janus kinase 3 (a protein tyrosine kinase, leukocyte)
UniProt Protein Name
Tyrosine-protein kinase JAK3
UniProt Synonym Protein Names
Janus kinase 3; JAK-3; Leukocyte janus kinase
UniProt Synonym Gene Names
UniProt Entry Name
JAK3_HUMAN
NCBI Summary for JAK3
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]
UniProt Comments for JAK3
JAK3: a non-receptor tyrosine-kinase of the Jak family expressed predominantly in immune cells. Mediates signal transduction via the common gamma-chain of cytokine receptors, including IL-2, -4, -7, -9, and -15. Interacts with members of the STAT (signal transduction and activators of transcription) family. Interacts with STAM2 and SHB. Contains two protein kinase domains. Mutations that abrogate JAK3 function cause an autosomal SCID (severe combined immunodeficiency disease). Inhibitor: R017s for organ transplants. Three differentially spliced isoforms have been described.
Protein type: EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Kinase, protein; TK group; JakA family
Chromosomal Location of Human Ortholog: 19p13.1
Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; endomembrane system; cytosol
Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; protein phosphatase binding; ATP binding; hormone receptor binding
Biological Process: cell migration; negative regulation of interleukin-12 production; peptidyl-tyrosine phosphorylation; negative regulation of interleukin-10 production; negative regulation of T-helper 1 cell differentiation; negative regulation of FasL biosynthetic process; enzyme linked receptor protein signaling pathway; protein amino acid phosphorylation; regulation of apoptosis; negative regulation of dendritic cell cytokine production; tyrosine phosphorylation of STAT protein; B cell differentiation; innate immune response; erythrocyte differentiation; T cell homeostasis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of T cell proliferation; inflammatory response; negative regulation of T cell activation; transmembrane receptor protein tyrosine kinase signaling pathway; STAT protein nuclear translocation
Disease: Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-negative, B Cell-positive, Nk Cell-negative
Research Articles on JAK3
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Products associated with JAK3 recombinant protein
Pathways associated with JAK3 recombinant protein
Diseases associated with JAK3 recombinant protein
Organs/Tissues associated with JAK3 recombinant protein
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