NP_067475.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,602 Da
NCBI Official Full Name
macrophage erythroblast attacher
NCBI Official Synonym Full Names
macrophage erythroblast attacher
NCBI Protein Information
macrophage erythroblast attacher
UniProt Protein Name
Macrophage erythroblast attacher
UniProt Synonym Protein Names
Erythroblast macrophage protein
UniProt Synonym Gene Names
UniProt Comments for MAEA
MAEA: Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Actin-binding; Cell adhesion; Cell development/differentiation; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5|5 B1
Cellular Component: actin cytoskeleton; contractile ring; cytoplasm; cytoskeleton; integral to plasma membrane; nuclear matrix; nucleus; spindle
Molecular Function: actin binding; ubiquitin-protein ligase activity
Biological Process: cell adhesion; cytoskeleton organization and biogenesis; enucleate erythrocyte development; erythrocyte development; negative regulation of apoptosis; negative regulation of myeloid cell apoptosis; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process
Research Articles on MAEA
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Products associated with anti-MAEA antibody
Diseases associated with anti-MAEA antibody
Organs/Tissues associated with anti-MAEA antibody
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