EAW60408.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
264,161 Da
NCBI Official Full Name
E1A binding protein p300
NCBI Official Synonym Full Names
E1A binding protein p300
NCBI Protein Information
histone acetyltransferase p300
UniProt Protein Name
Histone acetyltransferase p300
UniProt Synonym Protein Names
E1A-associated protein p300
UniProt Synonym Gene Names
NCBI Summary for EP300
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
UniProt Comments for EP300
p300: a histone acetyltransferase and transcriptional co-activator that regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Related to CPB (CREB-binding protein), and like CPB can stimulate transcription through activation of CREB. Specifically inhibited by the adenovirus oncoprotein E1A. A co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Methylated at R580 and R604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates the apoptotic response. Also methylated at R2142 by CARM1, which impairs interaction with NCoA2.
Protein type: Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 22q13.2
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: acetyltransferase activity; androgen receptor binding; beta-catenin binding; chromatin binding; damaged DNA binding; DNA binding; histone acetyltransferase activity; lysine N-acetyltransferase activity; nuclear hormone receptor binding; peptide N-acetyltransferase activity; protein binding; protein C-terminus binding; transcription activator binding; transcription coactivator activity; transcription factor binding; transferase activity, transferring acyl groups
Biological Process: apoptosis; circadian rhythm; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; fat cell differentiation; internal peptidyl-lysine acetylation; internal protein amino acid acetylation; N-terminal peptidyl-lysine acetylation; negative regulation of transcription from RNA polymerase II promoter; nervous system development; Notch signaling pathway; positive regulation of gene expression, epigenetic; positive regulation of interferon type I production; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription of target genes involved in unfolded protein response; protein amino acid acetylation; protein stabilization; regulation of autophagy; regulation of cell cycle; regulation of transcription, DNA-dependent; response to estrogen stimulus; response to hypoxia; stimulatory C-type lectin receptor signaling pathway; transcription-coupled nucleotide-excision repair
Disease: Colorectal Cancer; Rubinstein-taybi Syndrome 1; Rubinstein-taybi Syndrome 2
Research Articles on EP300
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Products associated with anti-EP300 antibody
Pathways associated with anti-EP300 antibody
Diseases associated with anti-EP300 antibody
Organs/Tissues associated with anti-EP300 antibody
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