NP_001010972.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,075 Da
NCBI Official Full Name
zyxin
NCBI Official Synonym Full Names
zyxin
NCBI Official Synonym Symbols
NCBI Protein Information
zyxin
UniProt Protein Name
Zyxin
UniProt Synonym Protein Names
Zyxin-2
NCBI Summary for ZYX
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]
UniProt Comments for ZYX
Zyxin: Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression. Interacts with HPV type 6 protein E6. Does not interact significantly with E6 proteins from HPV types 11, 16, or 18. Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the first LIM domain of TES. Interacts with NEBL (isoform 2). Belongs to the zyxin/ajuba family.
Protein type: Cell adhesion; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q34
Cellular Component: cell-cell adherens junction; cytoplasm; focal adhesion; integral to plasma membrane; nucleus; plasma membrane; stress fiber
Molecular Function: protein binding
Biological Process: cell adhesion; cell-cell signaling; cell-matrix adhesion; integrin-mediated signaling pathway; signal transduction; stress fiber formation; transforming growth factor beta receptor signaling pathway
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Products associated with anti-ZYX antibody
Pathways associated with anti-ZYX antibody
Diseases associated with anti-ZYX antibody
Organs/Tissues associated with anti-ZYX antibody
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