EDM01439.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,495 Da
NCBI Official Full Name
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
NCBI Official Synonym Full Names
KRAS proto-oncogene, GTPase
NCBI Protein Information
GTPase KRas
UniProt Protein Name
GTPase KRas
UniProt Synonym Protein Names
K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras
UniProt Synonym Gene Names
NCBI Summary for KRAS
oncogene and member of the small GTPase superfamily [RGD, Feb 2006]
UniProt Comments for KRAS
KRas: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Interacts with PHLPP. Interacts (active GTP-bound form preferentially) with RGS14. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 4q44
Cellular Component: cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; membrane; membrane raft; mitochondrion; plasma membrane
Molecular Function: GDP binding; GMP binding; GTP binding; GTPase activity; LRR domain binding; protein binding; protein complex binding
Biological Process: actin cytoskeleton organization; cytokine-mediated signaling pathway; female pregnancy; forebrain astrocyte development; homeostasis of number of cells within a tissue; insulin receptor signaling pathway; liver development; negative regulation of cell differentiation; negative regulation of neuron apoptosis; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of nitric-oxide synthase activity; positive regulation of protein phosphorylation; positive regulation of Rac protein signal transduction; Ras protein signal transduction; regulation of long-term neuronal synaptic plasticity; regulation of protein stability; regulation of synaptic transmission, GABAergic; response to glucocorticoid stimulus; response to mineralocorticoid stimulus; striated muscle cell differentiation; visual learning
Research Articles on KRAS
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Products associated with anti-KRAS antibody
Pathways associated with anti-KRAS antibody
Diseases associated with anti-KRAS antibody
Organs/Tissues associated with anti-KRAS antibody
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