NP_001268413.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,705 Da
NCBI Official Full Name
ADP-ribosylation factor GTPase-activating protein 1 isoform e
NCBI Official Synonym Full Names
ADP-ribosylation factor GTPase activating protein 1
NCBI Protein Information
ADP-ribosylation factor GTPase-activating protein 1; ARF1-directed GTPase-activating protein
UniProt Protein Name
ADP-ribosylation factor GTPase-activating protein 1
UniProt Synonym Protein Names
ADP-ribosylation factor 1 GTPase-activating protein; ARF1 GAP; ARF1-directed GTPase-activating protein
UniProt Synonym Gene Names
UniProt Entry Name
ARFG1_HUMAN
NCBI Summary for ARFGAP1
The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for ARFGAP1
ARF GAP1: GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs; GAPs, ARF; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 20q13.33
Cellular Component: synapse; cytosol
Molecular Function: protein binding; zinc ion binding; GTPase activator activity
Biological Process: protein transport; COPI coating of Golgi vesicle; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; unfolded protein response; retrograde vesicle-mediated transport, Golgi to ER; positive regulation of GTPase activity
Research Articles on ARFGAP1
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Products associated with anti-ARFGAP1 antibody
Pathways associated with anti-ARFGAP1 antibody
Diseases associated with anti-ARFGAP1 antibody
Organs/Tissues associated with anti-ARFGAP1 antibody
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