NP_000120.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
83,267 Da
NCBI Official Full Name
coagulation factor XIII A chain
NCBI Official Synonym Full Names
coagulation factor XIII A chain
NCBI Official Synonym Symbols
NCBI Protein Information
coagulation factor XIII A chain
UniProt Protein Name
Coagulation factor XIII A chain
UniProt Synonym Protein Names
Protein-glutamine gamma-glutamyltransferase A chain; Transglutaminase A chain
UniProt Synonym Gene Names
UniProt Entry Name
F13A_HUMAN
NCBI Summary for F13A1
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
UniProt Comments for F13A1
F13A1: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Defects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD). FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. Belongs to the transglutaminase superfamily. Transglutaminase family.
Protein type: Transferase; EC 2.3.2.13
Chromosomal Location of Human Ortholog: 6p25.3-p24.3
Cellular Component: extracellular region
Molecular Function: metal ion binding; protein-glutamine gamma-glutamyltransferase activity
Biological Process: blood coagulation; peptide cross-linking; platelet degranulation
Disease: Factor Xiii, A Subunit, Deficiency Of; Myocardial Infarction, Susceptibility To; Thrombophilia Due To Thrombin Defect
Research Articles on F13A1
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Pathways associated with anti-F13A1 antibody
Diseases associated with anti-F13A1 antibody
Organs/Tissues associated with anti-F13A1 antibody
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