NP_000587.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,904 Da
NCBI Official Full Name
insulin-like growth factor-binding protein 1
NCBI Official Synonym Full Names
insulin like growth factor binding protein 1
NCBI Official Synonym Symbols
AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1 [Similar Products]
NCBI Protein Information
insulin-like growth factor-binding protein 1
UniProt Protein Name
Insulin-like growth factor-binding protein 1
UniProt Synonym Protein Names
Placental protein 12; PP12
UniProt Synonym Gene Names
UniProt Entry Name
IBP1_HUMAN
NCBI Summary for IGFBP1
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
UniProt Comments for IGFBP1
IGFBP1: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 7p12.3
Cellular Component: extracellular region; extracellular space
Molecular Function: insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding; receptor binding
Biological Process: cellular protein metabolic process; insulin receptor signaling pathway; positive regulation of cell growth; regulation of insulin-like growth factor receptor signaling pathway; signal transduction; tissue regeneration
Research Articles on IGFBP1
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Products associated with anti-IGFBP1 antibody
Pathways associated with anti-IGFBP1 antibody
Diseases associated with anti-IGFBP1 antibody
Organs/Tissues associated with anti-IGFBP1 antibody
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