NP_003783.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,636 Da
NCBI Official Full Name
endothelial differentiation-related factor 1 isoform alpha
NCBI Official Synonym Full Names
endothelial differentiation related factor 1
NCBI Protein Information
endothelial differentiation-related factor 1
UniProt Protein Name
Endothelial differentiation-related factor 1
UniProt Synonym Protein Names
Multiprotein-bridging factor 1; MBF1
UniProt Synonym Gene Names
UniProt Entry Name
EDF1_HUMAN
NCBI Summary for EDF1
This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for EDF1
EDF1: Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription, coactivator/corepressor; RNA-binding; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: cytoplasm; intracellular; nucleolus; nucleus; transcription factor TFIID complex
Molecular Function: calmodulin binding; histone acetyltransferase activity; methyltransferase activity; protein binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity
Biological Process: endothelial cell differentiation; multicellular organismal development; positive regulation of DNA binding; positive regulation of transcription, DNA-dependent; regulation of lipid metabolic process; regulation of transcription, DNA-dependent; transcription, DNA-dependent
Research Articles on EDF1
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Products associated with anti-EDF1 antibody
Diseases associated with anti-EDF1 antibody
Organs/Tissues associated with anti-EDF1 antibody
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