NP_055180.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,604 Da
NCBI Official Full Name
heat shock protein beta-8
NCBI Official Synonym Full Names
heat shock protein family B (small) member 8
NCBI Official Synonym Symbols
H11; HMN2; CMT2L; DHMN2; E2IG1; HMN2A; HSP22 [Similar Products]
NCBI Protein Information
heat shock protein beta-8
UniProt Protein Name
Heat shock protein beta-8
UniProt Synonym Protein Names
Alpha-crystallin C chain; E2-induced gene 1 protein; Protein kinase H11; Small stress protein-like protein HSP22
UniProt Synonym Gene Names
UniProt Entry Name
HSPB8_HUMAN
NCBI Summary for HSPB8
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]
UniProt Comments for HSPB8
HSPB8: Displays temperature-dependent chaperone activity. Monomer. Interacts with HSPB1. Interacts with DNAJB6. By 17-beta-estradiol. Predominantly expressed in skeletal muscle and heart. Belongs to the small heat shock protein (HSP20) family.
Protein type: Heat shock protein
Chromosomal Location of Human Ortholog: 12q24.23
Cellular Component: cytoplasm; Golgi apparatus; intracellular; nucleoplasm; nucleus
Molecular Function: identical protein binding; protein binding; protein kinase activity
Disease: Charcot-marie-tooth Disease, Axonal, Type 2l; Neuronopathy, Distal Hereditary Motor, Type Iia
Research Articles on HSPB8
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Products associated with HSPB8 blocking peptide
Diseases associated with HSPB8 blocking peptide
Organs/Tissues associated with HSPB8 blocking peptide
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