NP_001167.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,098 Da
NCBI Official Full Name
rho GDP-dissociation inhibitor 3
NCBI Official Synonym Full Names
Rho GDP dissociation inhibitor gamma
NCBI Official Synonym Symbols
NCBI Protein Information
rho GDP-dissociation inhibitor 3
UniProt Protein Name
Rho GDP-dissociation inhibitor 3
UniProt Synonym Protein Names
Rho-GDI gamma
UniProt Synonym Gene Names
UniProt Entry Name
GDIR3_HUMAN
NCBI Summary for ARHGDIG
The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010]
UniProt Comments for ARHGDIG
RhoGDI gamma: Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP. Belongs to the Rho GDI family.
Protein type: Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis; Inhibitor
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: cytoplasmic membrane-bound vesicle; cytosol
Molecular Function: protein binding
Biological Process: negative regulation of cell adhesion; regulation of small GTPase mediated signal transduction; Rho protein signal transduction
Research Articles on ARHGDIG
Precautions
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Pathways associated with anti-ARHGDIG antibody
Diseases associated with anti-ARHGDIG antibody
Organs/Tissues associated with anti-ARHGDIG antibody
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