NP_001002814.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,304 Da
NCBI Official Full Name
rab11 family-interacting protein 1 isoform 3
NCBI Official Synonym Full Names
RAB11 family interacting protein 1 (class I)
NCBI Protein Information
rab11 family-interacting protein 1
UniProt Protein Name
Rab11 family-interacting protein 1
UniProt Synonym Protein Names
Rab-coupling protein
UniProt Synonym Gene Names
UniProt Entry Name
RFIP1_HUMAN
NCBI Summary for RAB11FIP1
This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013]
UniProt Comments for RAB11FIP1
RAB11FIP1: A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Homooligomer (isoform 2). Isoform 2 interacts with RAB4A, RAB11A, RAB11B and RAB25. According to PubMed:15280022, RAB4A binding to RAB11FIP1 is of very low affinity in vitro and in vivo. Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small intestine. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 8p11.22
Cellular Component: recycling endosome; phagocytic vesicle membrane; intracellular membrane-bound organelle; cytoplasm
Molecular Function: Rab GTPase binding
Biological Process: regulated secretory pathway; protein transport
Research Articles on RAB11FIP1
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Products associated with anti-RAB11FIP1 antibody
Pathways associated with anti-RAB11FIP1 antibody
Diseases associated with anti-RAB11FIP1 antibody
Organs/Tissues associated with anti-RAB11FIP1 antibody
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