NP_057333.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41,163 Da
NCBI Official Full Name
melanoma-associated antigen C2
NCBI Official Synonym Full Names
melanoma antigen family C, 2
NCBI Protein Information
melanoma-associated antigen C2; MAGE-C2 antigen; MAGE-E1 antigen; cancer/testis antigen 10; hepatocellular cancer antigen 587; hepatocellular carcinoma-associated antigen 587; melanoma antigen, family E, 1, cancer/testis specific
UniProt Protein Name
Melanoma-associated antigen C2
UniProt Synonym Protein Names
Cancer/testis antigen 10; CT10; Hepatocellular carcinoma-associated antigen 587; MAGE-C2 antigen; MAGE-E1 antigen
UniProt Synonym Gene Names
UniProt Entry Name
MAGC2_HUMAN
NCBI Summary for MAGEC2
This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009]
UniProt Comments for MAGEC2
MAGE-C2: Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.
Protein type: Cancer Testis Antigen (CTA)
Chromosomal Location of Human Ortholog: Xq27
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; ubiquitin protein ligase binding
Biological Process: cellular protein catabolic process; positive regulation of ubiquitin-protein ligase activity
Research Articles on MAGEC2
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Products associated with anti-MAGEC2 antibody
Diseases associated with anti-MAGEC2 antibody
Organs/Tissues associated with anti-MAGEC2 antibody
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