O14980.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
123,386 Da
NCBI Official Full Name
Exportin-1
NCBI Official Synonym Full Names
exportin 1
NCBI Protein Information
exportin-1
UniProt Protein Name
Exportin-1
UniProt Synonym Protein Names
Chromosome region maintenance 1 protein homolog
UniProt Synonym Gene Names
UniProt Entry Name
XPO1_HUMAN
NCBI Summary for XPO1
This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]
UniProt Comments for XPO1
Exportin-1: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of an nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. Belongs to the exportin family.
Protein type: Nuclear export; Nucleolus; Nuclear import; Karyopherin
Chromosomal Location of Human Ortholog: 2p15
Cellular Component: annulate lamellae; Cajal body; cytoplasm; cytosol; intracellular membrane-bound organelle; kinetochore; membrane; nuclear envelope; nuclear membrane; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex
Molecular Function: nucleocytoplasmic transporter activity; protein binding; protein domain specific binding; protein transporter activity; Ran GTPase binding; RNA binding; transporter activity
Biological Process: gene expression; mitotic cell cycle; mRNA transport; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; protein export from nucleus; regulation of mRNA stability; regulation of protein catabolic process; regulation of protein export from nucleus; response to drug; ribosomal large subunit export from nucleus; ribosomal small subunit export from nucleus; small GTPase mediated signal transduction; transforming growth factor beta receptor signaling pathway; viral infectious cycle; viral reproduction
Research Articles on XPO1
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Products associated with XPO1 blocking peptide
Pathways associated with XPO1 blocking peptide
Diseases associated with XPO1 blocking peptide
Organs/Tissues associated with XPO1 blocking peptide
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