NP_001093116.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
multidrug and toxin extrusion protein 2 isoform 2
NCBI Official Synonym Full Names
solute carrier family 47 (multidrug and toxin extrusion), member 2
NCBI Official Synonym Symbols
MATE2; MATE2K; MATE2-B; MATE2-K [Similar Products]
NCBI Protein Information
multidrug and toxin extrusion protein 2
UniProt Protein Name
Multidrug and toxin extrusion protein 2
UniProt Synonym Protein Names
Kidney-specific H(+)/organic cation antiporter; Solute carrier family 47 member 2
UniProt Synonym Gene Names
UniProt Entry Name
S47A2_HUMAN
NCBI Summary for SLC47A2
This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for SLC47A2
SLC47A2: Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes. Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: integral to membrane; plasma membrane
Molecular Function: drug transporter activity; antiporter activity
Biological Process: multidrug transport; transmembrane transport
Product References and Citations for anti-SLC47A2 antibody
Toyama, K., et al. Pharmacogenet. Genomics 20(2):135-138(2010) Kajiwara, M., et al. J. Hum. Genet. 54(1):40-46(2009) Ohta, K.Y., et al. J Pharm Pharm Sci 12(3):388-396(2009)
Research Articles on SLC47A2
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Products associated with anti-SLC47A2 antibody
Pathways associated with anti-SLC47A2 antibody
Diseases associated with anti-SLC47A2 antibody
Organs/Tissues associated with anti-SLC47A2 antibody
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