NP_000344.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
tyrosine aminotransferase
NCBI Official Synonym Full Names
tyrosine aminotransferase
NCBI Protein Information
tyrosine aminotransferase
UniProt Protein Name
Tyrosine aminotransferase
UniProt Synonym Protein Names
L-tyrosine:2-oxoglutarate aminotransferase
UniProt Synonym Gene Names
UniProt Entry Name
ATTY_HUMAN
NCBI Summary for TAT
This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008]
UniProt Comments for TAT
TAT: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. Defects in TAT are the cause of tyrosinemia type 2 (TYRO2); also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Protein type: Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - phenylalanine; EC 2.6.1.5; Amino Acid Metabolism - cysteine and methionine; Mitochondrial; Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis; Amino Acid Metabolism - tyrosine; Transferase
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: mitochondrion; cytosol
Molecular Function: amino acid binding; tyrosine transaminase activity; pyridoxal phosphate binding
Biological Process: response to mercury ion; glutamate metabolic process; L-phenylalanine catabolic process; tyrosine catabolic process; response to glucocorticoid stimulus; biosynthetic process; response to oxidative stress; 2-oxoglutarate metabolic process
Disease: Tyrosinemia, Type Ii
Product References and Citations for anti-TAT antibody
Liu, S., et al. Biosci. Rep. 29(2):103-109(2009) Pasternack, S.M., et al. Br. J. Dermatol. 160(3):704-706(2009) Maydan, G., et al. J. Inherit. Metab. Dis. 29(5):620-626(2006) Charfeddine, C., et al. Mol. Genet. Metab. 88(2):184-191(2006) Baharvand, H., et al. Int. J. Dev. Biol. 50(7):645-652(2006) Natt, E., et al. Proc. Natl. Acad. Sci. U.S.A. 89(19):9297-9301(1992)
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Products associated with anti-TAT antibody
Pathways associated with anti-TAT antibody
Diseases associated with anti-TAT antibody
Organs/Tissues associated with anti-TAT antibody
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